Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain

Authors :: Ohtsuki, Toshiho
Matsumoto, Masayasu
Hayashi, Yoko
Yamamoto, Kei
Kitagawa, Kazuo
Ogawa, Satoshi
Yamamoto, Shozo
Kamada, Takenobu
Source :: The American Journal of Physiology. March, 1995, Vol. 268 Issue 3, pH1249, 9 p.
Publication Year :: 1995
Abstract: The influence exerted by 5minutes of ischemia on brain 5-lipoxygenase (5-LO) and leukotriene C4 (LTC4) is investigated during reperfusion. The gerbil model of transient forebrain ischemia is used in the investigation. The investigation reveals that during reperfusion the production of LTC4 is reduced by superoxide dismutase and oxygen radical scavengers.

Subjects :: Reperfusion injury -- Research
Gerbils -- Research
Biological sciences

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