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Dietary lipid and iron status modulate lipid peroxidation in rats with induced adjuvant arthritis

Authors :
Muntane, Jordi
Mitjavila, Maria T.
Rodriguez, Maria C.
Puig-Parellada, Pere
Fernandez, Yvette
Mitjavila, Salvador
Source :
The Journal of Nutrition. July, 1995, Vol. 125 Issue 7, p1930, 8 p.
Publication Year :
1995

Abstract

We studied the effect of dietary lipids on iron metabolism and lipid peroxidation during induced adjuvant arthritis and/or iron overload in rats. We compared a control diet containing corn oil and rapeseed oil with a diet devoid of polyunsaturated fatty acids containing only tripalmitin as lipids. Four subgroups of rats were used with each diet: without further treatment, with induction of adjuvant arthritis, with iron overload, and with induction of adjuvant arthritis and iron overload. The profile of fatty acids present in plasma and in micro-somes changed in rats fed the tripalmitin diet. The level of tetra- and pentaunsaturated fatty acids was reduced, and the level of monounsaturated fatty acids and iron stores was increased with respect to control rats. Thus, ingestion of a tripalmitin diet reduced the substrate for lipid peroxidation, as shown by the decrease in thiobarbi-turic acid-reactive substances in plasma and conjugated dienes in hepatic microsomal fraction. Adjuvant arthritis and iron overload had a synergistic effect on lipid peroxi-dation and iron storage in liver. Further, in the hepatic microsomal fraction, tripalmitin reduced the levels of cytochrome P-450, and arthritis reduced the levels of cytochrome P-450 and [Ca.sup.2+] sequestration. Our results suggest that rats fed tripalmitin showed a reduction of lipid peroxidation induced by inflammation or by iron overload, because of the lack of polyunsaturated fatty acids in the diet, although tripalmitin usually increases the iron stores in the body and causes hepatic alterations. INDEXING KEY WORDS: adjuvant-induced arthritis; iron; polyunsaturated fatty acids; lipid peroxidation; rats

Details

ISSN :
00223166
Volume :
125
Issue :
7
Database :
Gale General OneFile
Journal :
The Journal of Nutrition
Publication Type :
Academic Journal
Accession number :
edsgcl.17341761