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Magic-angle spinning solid-state NMR spectroscopy of nanodisc-embedded human CYP3A4

Authors :
Kijac, Aleksandra Z.
Ying Li
Sligar, Stephen G.
Rienstra, Chad M.
Source :
Biochemistry. Dec 4, 2007, Vol. 46 Issue 48, 13696-13703
Publication Year :
2007

Abstract

A combination of magic-angle spinning (MAS) and solid state NMR (SSNMR) studies which provide structural information on human cytochrome P450 (CYP) 3A4 is described. The results help to understand ligand-specific binding events, allosteric regulation, and the impact of membrane interactions on CYP3A4 activity.

Subjects

Subjects :
Cytochrome P-450 -- Structure
Cytochrome P-450 -- Optical properties
Nuclear magnetic resonance spectroscopy -- Analysis
Biological sciences
Chemistry

Details

Language :
English
ISSN :
00062960
Volume :
46
Issue :
48
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.175334480

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