Synthesis and evaluation of the fully functionalized bleomycin A(sub 2) metal binding domain containing the 2-O-(3-O-carbamoyl-alpha-D-mannopyranosyl)-alpha-L-gulopyranosyl disaccharide

Bleomycin A(sub 2) can act as the medium for the oxidative cleavage of double-stranded DNA or RNA by a metal ion and oxygen dependant chemical process. The metal binding domain of the bleomycin A(sub 2) in the full natural product structure controls the selective determination of DNA cleavage although the presence of noncovalently linked tri-and tetrapeptide S cannot show the sequence selective DNA cleavage. The metal binding domain of bleomycin A(sub 2) consists of iron (II) and iron (III) complexes.