Genetic engineering of vein grafts resistant to atherosclerosis

Authors :: Mann, Michael J.
Gibbon, Gary H.
Kernoff, Robert S.
Diet, Frank P.
Tsao, Philip S.
Cooke, John P.
Kaneda, Yasufumi
Dzau, Victor J.
Source :: Proceedings of the National Academy of Sciences of the United States. May 9, 1995, Vol. 92 Issue 10, p4502, 5 p.
Publication Year :: 1995
Abstract: Intraoperative gene therapy may be possible in the treatment of occlusive vascular diseases by altering vein graft adaptation and preventing autologous vein graft failure. A genetic engineering technique tested in rabbits used antisense oligodeoxynucleotides to block medial smooth muscle cell proliferation. This decreased the grafts' susceptibility to atherosclerosis.

Subjects :: Gene therapy -- Methods
Vascular grafts -- Research
Atherosclerosis -- Care and treatment
Science and technology

ISSN :: 00278424
Volume :: 92
Issue :: 10
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.17841256

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