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m-Calpain in rat growth plate chondrocyte cultures: its involvement in the matrix mineralization process

Authors :
Yasuda, Tadashi
Shimizu, Katsuji
Nakagawa, Yasuaki
Yamamoto, Shingo
Niibayashi, Hiroshi
Yamamuro, Takao
Source :
Developmental Biology. July, 1995, Vol. 170 Issue 1, p159, 10 p.
Publication Year :
1995

Abstract

Mineralization of cartilage is a key step in the development and growth of bone. A mineralization experiment conducted with rates reveals that the enzyme m-Calpain, a Ca2+ -dependent neutral cysteine proteinase, controls the mineralization of cartilages by degrading proteoglycan during development of the cells. The amount of m-Calpain and its activity in pelleted cultures of rat growth plate chondrocytes increases as the chondrocytes differentiate into the hypertrophic cells and mineralization takes place. In the presence of m-Calpain inhibitors matrix mineralization is suppressed.

Details

ISSN :
00121606
Volume :
170
Issue :
1
Database :
Gale General OneFile
Journal :
Developmental Biology
Publication Type :
Academic Journal
Accession number :
edsgcl.17859592