Scrapie prions selectively modify the stress response in neuroblastoma cells

Authors :: Tatzelt, Jorg
Zuo, Jianru
Voellmy, Richard
Scott, Michael
Hartl, Ulrich
Prusiner, Stanley B.
Welch, William J.
Source :: Proceedings of the National Academy of Sciences of the United States. March 28, 1995, Vol. 92 Issue 7, p2944, 6 p.
Publication Year :: 1995
Abstract: Analysis of neuroblastoma scrapie-infected N2a (ScN2a) cells for the expression and cellular distribution of heat shock proteins (Hsp) to find whether proteins participate in the transformation of cellular prion protein into the scrapie isoform PrP(super Sc) shows changes in subcellular translocations of particular Hsps in ScN2a cells. This may represent cellular response to the collection of PrP(super Sc). The distribution of Hsp73 was unaffected by heat shock.

Subjects :: Neuroblastoma -- Research
Heat shock proteins -- Analysis
Science and technology

ISSN :: 00278424
Volume :: 92
Issue :: 7
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.17918488

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