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Modification of rhodamine staining allows identification of hematopoietic stem cells with preferential short-term or long-term bone marrow-repopulating ability
- Source :
- Proceedings of the National Academy of Sciences of the United States. Sept 12, 1995, Vol. 92 Issue 19, p8901, 5 p.
- Publication Year :
- 1995
-
Abstract
- The concentration of P-glycoprotein expression in hematopoietic stem cells is high and it is possible to separate cells responsible for long-term bone marrow repopulating ability from those exhibiting short-term repopulating ability by the decrease in the mitochondrial rhodamine (Rho)-binding capability. A modification of Rho staining was developed to study the intake of Rho into hematopoietic cells. A large portion of the cells become Rho positive while some become Rho negative.
- Subjects :
- Hematopoietic stem cells -- Research
Science and technology
Subjects
Details
- ISSN :
- 00278424
- Volume :
- 92
- Issue :
- 19
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.18009416