Relaxin stimulates myometrial calcium-activated potassium channel via protein kinase A

The hormone Relaxin uses a protein kinase A-mediated mechanism to stimulate the K(sub Ca) channels resulting in myometrial quiescence. Relaxin stimulates K(sub Ca) channels in cell-attached patches in a cell line derived from term pregnant human myometrium. The Relaxin hormone is higher during pregnancy and can suppress myometrial contractile activity.