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Bifunctional asymmetric catalysis: cooperative Lewis acid/base systems

Authors :
Paull, Daniel H.
Abraham, Ciby J.
Scerba, Michael T.
Alden-Danforth, Ethan
Lectka, Thomas
Source :
Accounts of Chemical Research. May, 2008, Vol. 41 Issue 5, 655-663
Publication Year :
2008

Abstract

The cooperative Lewis acid and base systems are analyzed to explain the significance of various bifunctional asymmetric catalytic methods. The coordination and activation of an electrophile by a Lewis acid is shown to lead to an increase in the yields and reaction rates of the system.

Details

Language :
English
ISSN :
00014842
Volume :
41
Issue :
5
Database :
Gale General OneFile
Journal :
Accounts of Chemical Research
Publication Type :
Academic Journal
Accession number :
edsgcl.180534417