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Inhibition of herpes simplex virus replication by antisense oligo-2'-O-methylribonucleoside methylphosphonates
- Source :
- Biochemistry. Nov 14, 1995, Vol. 34 Issue 45, p14617, 4 p.
- Publication Year :
- 1995
-
Abstract
- The interaction between the antisense activity and oligomer binding affinity in cell cultures suggests that oligo-2'-O-methylribonucleoside methylphosphonates (mr-OMPs) can be used as effective antisense reagents. The capacity of mr-OMP to bind to its RNA target is higher than that of oligo-2'-deoxyribonucleoside methyphosphonate. The mr-OMP also inhibits herpes simplex virus type 1 (HSV-1) replication in HSV-1 infected Vero cells in culture.
Details
- ISSN :
- 00062960
- Volume :
- 34
- Issue :
- 45
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.18094963