Inhibition of herpes simplex virus replication by antisense oligo-2'-O-methylribonucleoside methylphosphonates

The interaction between the antisense activity and oligomer binding affinity in cell cultures suggests that oligo-2'-O-methylribonucleoside methylphosphonates (mr-OMPs) can be used as effective antisense reagents. The capacity of mr-OMP to bind to its RNA target is higher than that of oligo-2'-deoxyribonucleoside methyphosphonate. The mr-OMP also inhibits herpes simplex virus type 1 (HSV-1) replication in HSV-1 infected Vero cells in culture.