Reversal of intrinsic DNA bends in the IFN-beta gene enhancer by transcription factors and the architectural protein HMG I(Y)

Binding of the transcription factor NF-kappa-B and the activating transfer factor ATF-2/c-Jun to the enhanceosome positive regulatory domains (PRDs) PRDII and PRDIV respectively changes the DNA curvature of the PRDs. The high mobility group protein HMG I(Y) alters the structure of these complexes. The conformational changes increase protein-protein interaction in the enhanceosome. The enhanceosome participates in the transcriptional activation of the interferon-beta gene in response to viral infection.