Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor

Fyn is a protein tyrosine kinase that controls the progression of cytokinesis in B lymphocyte progenitor (pro B) cells. Fyn is present in the midspace of dividing pro B cells, at anaphase. The cytokinesis of fyn(-) pro B cells decreases under a serum containing culture condition. The serum-free condition blocks the fyn(-) pro B cell entry into the late telophase. Details of a study conducted on pro B cells from various strains of mice, in a serum-free and chemically defined culture condition, are given.