Inhibition of G-protein beta-subunit functions by phosducin-like protein

The phosducin-like protein (PhLP) was the resultant protein formed after cDNA isolation from rat brain with high phosducin homology. PhLP variants displayed indicated strong similarities with phosducin, although substantial differences were observed for N terminus length. PhLP showed binding capability with G-protein beta subunits through an unknown interaction process, implying a possible role in endogenous regulation of G-protein function.