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ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis
- Source :
- Biochemistry. Sept 2, 2008, Vol. 47 Issue 35, 9054-9056
- Publication Year :
- 2008
-
Abstract
- The purification and characterization of the ThiC protein from Salmonella enterica is reported. The results obtained provide insight into the activity of ThiC, which carries an oxygen labile [Fe-S] cluster critical for generation of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate (HMP-PP).
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 47
- Issue :
- 35
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.185365093