Distortion-dependent unhooking of interstrand cross-links in mammalian cell extracts

Authors :: Smeaton, Michael B.
Hlavin, Erica M.
Mason, Tracey McGregor
Noronha, Anne M.
Wilds, Christropher J.
Miller, Paul S.
Source :: Biochemistry. Sept 16, 2008, Vol. 47 Issue 37, 9920-9930
Publication Year :: 2008
Abstract: Interstrand cross-linked (ICL) linear DNA duplexes are used to examine cross-link processing in mammalian whole-cell extracts. The results have shown that in DNA not undergoing transcription or replication, distortions induced by the presence of an ICL has contributed to initial cross-link recognition and processing.

Subjects :: DNA replication -- Research
Proteins -- Crosslinking
Proteins -- Research
Cell research
Biological sciences
Chemistry

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