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Nondestructive direct determination of heroin in seized illicit street drugs by diffuse reflectance near-infrared spectroscopy
- Source :
- Analytical Chemistry. Oct 1, 2008, Vol. 80 Issue 19, p7257, 9 p.
- Publication Year :
- 2008
-
Abstract
- A new method has been developed for the fast and nondestructive direct determination of heroin in seized street illicit drugs using partial least-squares regression analysis of diffuse reflectance near-infrared spectra. Data were obtained from untreated samples placed in standard glass chromatography vials. A heterogeneous population of 31 samples, previously analyzed by a reference method, was employed to build the calibration model and to have a separated validation set. Based on the use of zero-order data for a calibration set of 21 samples, after standard normal variate and quadratic linear removed baseline correction (detrending), in the wavelength range from 1111 to 1647 nm, 8 PLS factors were enough to obtain a root-mean-square error of prediction of 1.3% w/w, with a quality coefficient of 10% for the estimation of the accuracy error in the prediction of heroin concentration in unknown samples and a residual predictive deviation of 5.4.
Details
- Language :
- English
- ISSN :
- 00032700
- Volume :
- 80
- Issue :
- 19
- Database :
- Gale General OneFile
- Journal :
- Analytical Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.187050166