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Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase
- Source :
- Proceedings of the National Academy of Sciences of the United States. Sept 3, 1996, Vol. 93 Issue 18, p9704, 6 p.
- Publication Year :
- 1996
-
Abstract
- Chimeric mice in which lymphocytes are deficient in the Syk tyrosine kinase have been created. Compared with Syk-positive controls, mice with Syk -/- lymphocytes display substantial depletion of intraepithelial [Gamma][Delta] T cells in the skin and gut, with developmental arrest occurring after antigen receptor gene rearrangement. In this dependence on Syk, subsets of intraepithelial [Gamma][Delta] T cells are similar to B cells, but distinct from splenic [Gamma][Delta] T cells that develop and expand in Syk-deficient mice. The characteristic associations of certain T-cell receptor V[Gamma]/V[Delta] gene rearrangements with specific epithelia are also disrupted by Syk deficiency.
- Subjects :
- T cells -- Research
Protein kinases -- Research
Science and technology
Subjects
Details
- ISSN :
- 00278424
- Volume :
- 93
- Issue :
- 18
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.18799633