The synthesis of C-trisaccharides exploiting the stereochemical diversity of a central sugar

A general approach for the synthesis of C-trisaccharides bearing 1,2 sugar branching was developed using the H type I blood group determinant. Two pendant sugars were attached to the terminus of the trisaccharide. A central hexose core was created for the C-trisaccharide and permutational mutations to these core caused changes to the trisaccharide's overall conformation. The steps to the synthesis of more trisaccharides bearing a variety of structures are discussed.