Endotoxin stimulates lymphocyte-endothelial interactions in rat intestinal Peyer's patches and villus mucosa

Endotoxins promote the interactions between lymphocytes and endothelium in the intestinal Peyer's patches and villus mucosa of rats. Lymphocytes from the blood are utilized by the rat intestinal tissues in the presence of a constant antigen stimuli. T lymphocytes show rolling and adhesive behavior in microvessels of both Peyer's patches and villi. These behaviors are regulated by alpha-4-integrins, and partly by beta-2-integrins. In the capillaries of the intestinal mucosa of lipopolysaccharide-treated rats, adhesion occurs without rolling and is alpha-4-integrin-independent.