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Selective cytotoxic Ru(II) arene Cp* complex salts [[R-PhRuCp*].sup.+][X.sup.-] for X =: B[F.sub.4.sup.-], P[F.sub.6.sup.-], and B[Ph.sub.4.sup.-]

Selective cytotoxic Ru(II) arene Cp* complex salts [[R-PhRuCp*].sup.+][X.sup.-] for X =: B[F.sub.4.sup.-], P[F.sub.6.sup.-], and B[Ph.sub.4.sup.-]

Authors :
Loughrey, Bradley T.
Healy, Peter C.
Parsons, Peter G.
Williams, Michael L.
Source :
Inorganic Chemistry. Oct 6, 2008, Vol. 47 Issue 19, 8589-8591
Publication Year :
2008

Abstract

The article describes the synthesis and characterization of a series of ionic Ru(II) arene Cp* sandwich complexes. The results from screening for cytotoxicity against a range of human tumor cell lines and normal human cells reveal the complexes to exhibit promising anticancer activity that varies with changes in the arene ligand and the anionic counterion.

Details

Language :
English
ISSN :
00201669
Volume :
47
Issue :
19
Database :
Gale General OneFile
Journal :
Inorganic Chemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.189768776