Sustained low levels of fibroblast growth factor-1 promote persistent microvascular network formation

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjsurg.2006.08.012 Byline: Shiri Uriel (a), Eric M. Brey (a)(b), Howard P. Greisler (b)(c)(d) Keywords: Neovascularization; Angiogenesis; FGF-1; Endothelial cells; Capillary regression Abstract: Therapeutic neovascularization using high growth factor concentrations may lead to transient vessel formation and abnormal microvascular structure. The goal of this study was to quantify temporal and concentration effects of fibroblast growth factor-1 (FGF-1) on the persistence and morphology of microvascular networks. Author Affiliation: (a) Pritzker Institute of Medical Engineering, Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA (b) Research Services, Hines VA Hospital, Hines, IL, USA (c) Department of Surgery, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA (d) Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, Maywood, IL, USA Article History: Received 22 May 2006; Revised 2 August 2006 Article Note: (footnote) Supported by grants from the NIH (R01-HL 41272, F32-HL074594) and the Veterans Administration (HPG, EMB).