Clinical peritoneal dialysis solutions modulate white blood cell-intestinal vascular endothelium interaction

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjsurg.2006.08.016 Byline: James E. Campbell (a), Richard N. Garrison (a)(b)(c), El Rasheid Zakaria (a)(b) Keywords: Hemorrhagic shock; Peritoneal dialysis solution; Neutrophils; Vascular endothelium Abstract: Hemorrhagic shock (HS) with conventional resuscitation (CR) (HSCR) primes neurophils and modulates leukocyte (WBC)-endothelium interaction as part of an exaggerated systemic inflammatory response. We hypothesize that topical application of clinical peritoneal dialysis solutions (PD) modulates such interaction. Author Affiliation: (a) Department of Physiology, Louisville, KY, USA (b) Department of Biophysics, University of Louisville, Louisville, KY, USA (c) Veterans Administration Medical Center, Louisville, KY, USA Article History: Received 5 June 2006; Revised 7 August 2006 Article Note: (footnote) Supported by a VA Merit Review grant and by NIH research Grant No. 5R01 HL076160-03, funded by the National Heart, Lung, and Blood Institute and the United States Army Medical Resources and Material Command.