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Oxo-ester mediated native chemical ligation: concept and applications
- Source :
- Journal of the American Chemical Society. Nov 26, 2008, Vol. 130 Issue 47, 15814-15816
- Publication Year :
- 2008
-
Abstract
- A major simplification is described in the field of native chemical ligation (NCL). The feasibility of NCL with oxo- rather than thioesters is demonstrated by balancing acyl donor potential with substrate stability.
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 130
- Issue :
- 47
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.192539013