Back to Search
Start Over
Osmium-promoted electrophilic substitution of anisoles: a versatile new method for the incorporation of carbon substituents
- Source :
- Journal of Organic Chemistry. Jan 10, 1997, Vol. 62 Issue 1, p130, 7 p.
- Publication Year :
- 1997
-
Abstract
- The coordination of the pentaammineosmium(II) metal center to different kinds of anisoles has been found to radically increase the nucleophilicity of the arene. Reactions occur with a large variety of carbon electrophiles in the presence of acidic acetonitrile at -40 degrees C to produce characterizable 4H-anisolium intermediates. Upon deprotonation and decomplexation, the 4-substituted anisole is returned in overall yields usually greater than 80 %.
- Subjects :
- Osmium -- Research
Aromatic compounds -- Research
Biological sciences
Chemistry
Subjects
Details
- ISSN :
- 00223263
- Volume :
- 62
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.19291610