Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids

Authors :: Liang Sun
Xudong Geng
Geney, Raphael
Yuan Li
Simmerling, Carlos
Zhong Li
Shujun Xia
Lauher, Joseph W.
Horwitz, Susan B.
Veith, Jean M.
Pera, Paula
Bernacki, Ralph J.
Ojima, Iwao
Source :: Journal of Organic Chemistry. Dec 19, 2008, Vol. 73 Issue 24, 9584-9593
Publication Year :: 2008
Abstract: The Ru-catalyzed synthesis of novel C14 position of the baccatin moiety and the ortho position of C3'N-benzoyl group (C14-C3'BzN)-linked macrocyclic taxoids (SB-T-2053) and (SB-T-2054) that mimic the 'REDOR-taxol' structure, paclitaxel is described. The results revealed that SB-T-2054 is the most active compound that exhibited similar potency and structure as that of paclitaxel.

Subjects :: Benzoyl peroxide -- Chemical properties
Catalysis -- Analysis
Paclitaxel -- Chemical properties
Paclitaxel -- Structure
Ruthenium -- Chemical properties
Biological sciences
Chemistry

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