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A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
- Source :
- Cell. Jan 10, 1997, Vol. 88 Issue 1, p97, 11 p.
- Publication Year :
- 1997
-
Abstract
- SUMO-1, a novel peptide of 101 amino acids, has been found to be covalently linked to the mammalian Ran GTPase-activating protein RanGAP1 in an adenosine triphosphate-dependent reaction. SUMO-1 exhibits a homology to ubiquitin, a 76-residue protein found in eukaryotes. Data indicate that the polypeptide is involved in protein targeting and not degradation. At least three additional intranuclear proteins are modified with SUMO-1 or with a protein closely resembling it.
- Subjects :
- Polypeptides -- Research
Ubiquitin -- Research
Biological sciences
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 88
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.19319698