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Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production

Authors :
Murakami, Kazunori
Okajima, Kenji
Uchiba, Mitsuhiro
Johno, Masayoshi
Nakagaki, Tomohiro
Okabe, Hiroaki
Takatsuki, Kiyoshi
Source :
The American Journal of Physiology. Feb, 1997, Vol. 272 Issue 2, pL197, 6 p.
Publication Year :
1997

Abstract

Specific pathogen-free male Wistar rats treated with lipopolysaccharide (LPS) were analyzed to determine the efficiency of activated protein C (APC) in preventing LPS-induced pulmonary vascular injury. Analysis of rats exhibiting LPS-induced organ damage indicated the role of APC in reducing LPS-induced pulmonary vascular injury by inhibiting the synthesis of tumor necrosis factor. Furthermore, prophylactic administration of APC before LPS prevented endothelial cell damage by inhibiting cytokine production.

Details

ISSN :
00029513
Volume :
272
Issue :
2
Database :
Gale General OneFile
Journal :
The American Journal of Physiology
Publication Type :
Academic Journal
Accession number :
edsgcl.19359698