Estrogen receptor-[alpha] thymidine and adenine repeat polymorphism and endothelial fibrinolytic regulation in postmenopausal women

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2005.01.028 Byline: Greta L. Hoetzer (a), Heather M. Irmiger (a), Brian L. Stauffer (a)(b), Christopher A. DeSouza (a)(c) Abstract: We hypothesized that the capacity of the endothelium to release tissue-type plasminogen activator is blunted in postmenopausal women with long (TA).sub.n repeat alleles ([greater than or equal to]18 repeats). Author Affiliation: (a) Department of Integrative Physiology, Integrative Vascular Biology Laboratory, University of Colorado, Boulder, CO (b) Department of Medicine, Divisions of Cardiology (c) Geriatrics, University of Colorado, Health Sciences Center, Denver, CO Article History: Received 27 September 2004; Revised 19 November 2004; Accepted 11 January 2005 Article Note: (footnote) Supported by National Institutes of Health awards HL68030 and DK62061 and American Heart Association award 0255921Z.