First-trimester trophoblast cell model gene response to hypoxia

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2006.01.067 Byline: Nikki Koklanaris (a), Jerome C. Nwachukwu (b), S. Joseph Huang (c), Seth Guller (c), Ksenia Karpisheva (b), Michael Garabedian (b), Men-Jean Lee (c) Abstract: Trophoblast invasion, which sets the stage for placentation and pregnancy outcome, likely occurs in a hypoxic environment. We used microarray technology in a trophoblast cell line to identify hypoxia-responsive genes that may impact placentation. Author Affiliation: (a) Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine (b) Department of Microbiology, New York University School of Medicine, New York, NY (c) Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT Article History: Received 8 December 2005; Revised 9 January 2006; Accepted 17 January 2006 Article Note: (footnote) Presented at the 26th Annual Meeting of the Society for Maternal Fetal Medicine, January 30-February 4, 2006, Miami, FL.