Localization and expression of prostaglandin E.sub.2 receptors in human placenta and corresponding fetal membranes with labor

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2006.01.082 Byline: Peta L. Grigsby (a), Suren R. Sooranna (b), Diane E. Brockman (a), Mark R. Johnson (b), Leslie Myatt (a) Abstract: The effects of prostaglandin E.sub.2 (PGE.sub.2) are mediated through G-protein coupled receptors, acting via different second messengers. The aim of this study was to characterize the temporal and tissue specific localization and expression of the PGE.sub.2 receptor subtypes (EP1-4) in uteroplacental tissues during human pregnancy. Author Affiliation: (a) Department of Obstetrics and Gynceology, University of Cincinnati, Medical College, Cincinnati, OH (b) Imperial College Parturition Research Group, Department of Maternal Fetal Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK Article History: Received 31 October 2005; Revised 11 January 2006; Accepted 20 January 2006 Article Note: (footnote) Supported by the National Institutes of Health grant NIH HD 40285-01A1.