Does reperfusion injury still cause significant mortality after lung transplantation?

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2008.11.007 Byline: Gorav Ailawadi, Christine L. Lau, Philip W. Smith, Brian R. Swenson, Sara A. Hennessy, Courtney J. Kuhn, Lynn M. Fedoruk, Benjamin D. Kozower, Irving L. Kron, David R. Jones Abbreviations: ATGAM, antithymocyte globulin; CMV, cytomegalovirus; COPD, chronic obstructive pulmonary disease; ECMO, extracorporeal membrane oxygenation; Fio.sub.2, fraction of inspired oxygen; ISHLT, International Society for Heart and Lung Transplantation; LTX, lung transplantation; NO, nitric oxide; OI, oxygenation index; OPO, organ procurement organization; P/F, Pao.sub.2/Fio.sub.2; PGD, primary graft dysfunction; PPH, primary pulmonary hypertension; RI, reperfusion injury Abstract: Severe reperfusion injury after lung transplantation has mortality rates approaching 40%. The purpose of this investigation was to identify whether our improved 1-year survival after lung transplantation is related to a change in reperfusion injury. Author Affiliation: Department of Surgery, University of Virginia, Charlottesville, Va Article History: Received 9 May 2008; Revised 21 August 2008; Accepted 6 November 2008 Article Note: (footnote) Read at the Eighty-eighth Annual Meeting of the American Association for Thoracic Surgery, San Diego, Calif, May 12-14, 2008., Supported in part through National Institutes of Health Cardiovascular Surgery Research Training grant T32 HL007849 (to PWS).