Changes in P2Y1 nucleotide receptor activity during the development of rat salivary glands

The expression and distribution P2Y G protein-coupled receptors in rat salivary gland cells were analyzed by reverse transcriptase-polymerase chain reaction. The expression of P2Y receptors in rat salivary glands was developmentally regulated via postranslational and translational modification. Furthermore, salivary gland cells from older rats exhibited lower levels of P2Y receptor messenger RNA expression compared to the salivary gland cells of postnatal rats.