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Inhibition of HIV infection of H9 cells by chlorpromazine derivatives
- Source :
- Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. May 1, 1997, Vol. 15 Issue 1, p16, 5 p.
- Publication Year :
- 1997
-
Abstract
- Chlorpromazine may be capable of preventing HIV from infecting T cells especially when used in conjunction with zidovudine. The initial step in T cell infection occurs when the gp120 viral protein binds to the CD4 T cell receptor. This involves an electrostatic attachment that could be blocked by charged molecules such as chlorpromazine. Researchers studied several derivatives of chlorpromazine and found that 7,8-dioxo-chlorpromazine blocked the attachment of recombinant gp120 and also prevented infection of a T cell culture in the presence of zidovudine.
- Subjects :
- HIV infection -- Prevention
Chlorpromazine -- Physiological aspects
T cells
Health
Subjects
Details
- ISSN :
- 10779450
- Volume :
- 15
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
- Publication Type :
- Periodical
- Accession number :
- edsgcl.19614839