Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells

The effects of internal adenosine triphosphate (ATP) concentration, levcromakalim and glibenclamide on adenosine triphosphate (ATP)-sensitive potassium (KATP) channels were analyzed in isolated rabbit aortic cells. Administration of levcromakalim and glibenclamide in freshly dissociated rabbit aortic endothelial cells activated several distinct conductance channels. Furthermore, five types of KATP conductances were detected based on their sensitivity to ATP and pharmacology.