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Characterization of sphingosine 1-phoshate-induced actions and its signaling pathways in rat hepatocytes
- Source :
- The American Journal of Physiology. May, 1997, Vol. 272 Issue 5, pG1091, 7 p.
- Publication Year :
- 1997
-
Abstract
- The effects of sphingosine 1-phosphate (S-1-P) and lysophosphatidic acid (LPA) on glycogen phosphorylase stimulation were analyzed in freshly prepared and primary cultured hepatocytes isolated from adult rats. The presence of S-1-P and LPA in primary cultured rat hepatocytes induced the stimulation of glycogen phosphorylase which was mediated by phospholipase C activation and elevations in [Ca2+]i. Furthermore, S-1-P attenuated adenosine 3',5'-cyclic monophosphate accumulation in rat hepatocytes.
- Subjects :
- Liver cells -- Physiological aspects
Cellular control mechanisms -- Physiological aspects
Carrier proteins -- Physiological aspects
Phospholipases -- Physiological aspects
Glycogen metabolism -- Physiological aspects
Cellular signal transduction -- Physiological aspects
Biological sciences
Subjects
Details
- ISSN :
- 00029513
- Volume :
- 272
- Issue :
- 5
- Database :
- Gale General OneFile
- Journal :
- The American Journal of Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.19658327