Femtosecond laser-induced ionization/dissociation of protonated peptides

The implementation and results from a novel strategy for peptide sequence and modification analysis (femtosecond laser-induced ionization/dissociation (fs-LID)) involving the use of ultrashort laser pulses for energy deposition and nonergodic dissociation in a quadrupole ion trap mass spectrometer are presented. The studies have shown that fs-LID is a viable alternate ion activation strategy for peptide sequence and modification analysis.