Pten, Tumorigenesis, and Stem Cell Self-Renewal

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2006.04.006 Byline: Derrick J. Rossi (1), Irving L. Weissman (1)(2) Abstract: Self-renewal pathways crucial for maintaining stem cells are deregulated in cancer, raising the spectre that cancer therapies targeting such pathways might also ablate normal stem cells. As report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms. Author Affiliation: (1) Department of Pathology, Stanford University School of Medicine, Beckman Center B259, 279 Campus Drive, Stanford, CA 94305, USA (2) Institute of Stem Cell Biology and Regenerative Medicine and Developmental Biology, Stanford University School of Medicine, Beckman Center B259, 279 Campus Drive, Stanford, CA 94305, USA