Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease

Background: Prevention of coronary heart disease (CHD) in high-risk subjects. Objective: To investigate the associations of dietary intake of alpha-linolenic acid (ALA) and linoleic acid (LA) as assessed by food frequency questionnaire and in the plasma cholesteryl ester (CE), with CHD risk factors. Design: Baseline data of a double-blind, randomized placebo-controlled trial. Subjects have hypercholesterolemia (6.0-8.0 mmol/l) and at least two other CHD risk factors (n=266). Results: The reported dietary ALA and LA intakes and the LA/ALA ratio were associated with the contents in the CE (r=0.37, r=0.21, and r=0.42, respectively; P < 0.01). In multivariate analysis, CE ALA was inversely associated with diastolic blood pressure (r= - 0.13; P < 0.05) and positively with serum triacylglycerol (r=0.13; P < 0.05), and CE LA was inversely associated with serum triacylglycerol (r=- 0.32; P < 0.01). The CE LA/ALA ratio was strongly inversely associated with CE ALA (r= - 0.95; P < 0.01). In the lowest quintile of CE ALA, mean dietary intake was 0.4 energy % ALA (1.2 g/day), 8.4 energy % LA and an LA/ALA ratio of 21, and in the highest quintile 0.6 energy % ALA (1.7 g/day), 6.8 energy % LA and 12 (ratio). In the lowest quintile of CE ALA the diastolic blood pressure was 4 mmHg lower (P trend < 0.05), and the serum triacylglycerol 0.3 mmol/l higher (P trend NS) when compared with the top quintile. Conclusions: In a CHD high-risk population with LA-rich background diet, these cross-sectional data suggest that replacing LA in the diet by ALA may decrease diastolic blood pressure, and may increase serum triacylglycerol concentration. Sponsorship: Dutch Prevent fund grant no. 28-2757; Unilever (margarine). Descriptors: alpha-linolenic acid; linoleic acid; plasma cholesteryl ester; CHD risk factors; blood pressure; serum triacylglycerol European Journal of Clinical Nutrition (2000) 54, 865-871
Introduction The MARGARIN study is a prevention project of coronary heart disease (CHD) through a high-risk approach. The study group is composed of 266 hypercholesterolemic subjects with at least two [...]