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A new convergent approach to the polycyclic framework of dynemicin A

Authors :
Escudero, Sonia
Perez, Dolores
Guitian, Enrique
Castedo, Luis
Source :
Journal of Organic Chemistry. May 16, 1997, Vol. 62 Issue 10, p3028, 2 p.
Publication Year :
1997

Abstract

The polycyclic framework of dynemicin A and analogs with different planar moieties were synthesized based on a the Diels-Alder reaction of pyrones. The synthetic strategy was characterized by the formation of an intermediate tetrahydrobenzophenanthiridine from the Diels-Alder reaction of pyrones with benzyne followed by the thermal decomposition of the resulting compound and CO2 extrusion. The intermediate product was subjected to successive reactions that led to the formation of methylated anthraquinones that were transformed to dynemicin A.

Details

ISSN :
00223263
Volume :
62
Issue :
10
Database :
Gale General OneFile
Journal :
Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.19940525