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Oxytocin is an anabolic bone hormone
- Source :
- Proceedings of the National Academy of Sciences of the United States. April 28, 2009, Vol. 106 Issue 17, p7149, 6 p.
- Publication Year :
- 2009
-
Abstract
- We report that oxytocin (OT), a primitive neurohypophyseal hormone, hitherto thought solely to modulate lactation and social bonding, is a direct regulator of bone mass. Deletion of OT or the OT receptor (Oxtr) in male or female mice causes osteoporosis resulting from reduced bone formation. Consistent with low bone formation, OT stimulates the differentiation of osteoblasts to a mineralizing phenotype by causing the up-regulation of BMP-2, which in turn controls Schnurri-2 and 3, Osterix, and ATF-4 expression. In contrast, OT has dual effects on the osteoclast. It stimulates osteoclast formation both directly, by activating NF-[kappa]B and MAP kinase signaling, and indirectly through the up-regulation of RANK-L. On the other hand, OT inhibits bone resorption by mature osteodasts by triggering cytosolic [Ca.sup.2+] release and NO synthesis. Together, the complementary genetic and pharmacologic approaches reveal OT asa novel anabolic regulator of bone mass, with potential implications for osteoporosis therapy. osteoblast | osteoclast | osteoporosis | pituitary hormones | bone density
- Subjects :
- Oxytocin -- Properties
Bones -- Density
Bones -- Research
Science and technology
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 106
- Issue :
- 17
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.199912306