The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases

Authors :: Plafker, Kendra S.
Singer, Jeffrey D.
Plafker, Scott M.
Source :: Biochemistry. April 21, 2009, Vol. 48 Issue 15, 3527-3537
Publication Year :: 2009
Abstract: Several biochemical studies are conducted to explain the reactions of the ubiquitin conjugating enzyme (E2), UbcM2 with the different components of cullin3 (CUL3) based E3 ligases. The results clearly demonstrate that the class III E2s act as novel regulators of the cullin ligases.

Subjects :: Enzyme binding -- Analysis
Ligases -- Chemical properties
Ligases -- Structure
Mutation (Biology) -- Analysis
Ubiquitin -- Chemical properties
Biological sciences
Chemistry

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