Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Authors :: Uehata, Massayoshi
Ishizaki, Toshimasa
Satoh, Hirouki
Ono, Takashi
Kawahara, Toshio
Morishita, Tamami
Tamakawa, Hiroki
Yamagami, Keiji
Inui, Jun
Maekawa, Midori
Narumiya, Shuh
Source :: Nature. Oct 30, 1997, Vol. 389 Issue 6654, p990, 5 p.
Publication Year :: 1997
Abstract: Smooth-muscle contraction is controlled by the cytosolic Casuper2+ concentration and by the Casuper2+ myofilament sensitivity. It is shown than pyridine derivative Y-27632, inhibits smooth-muscle contraction selectively, by inhibiting Casuper2+ sensitization. This target is a Rho-associated protein kinase p160ROCKsuper7.

Subjects :: Smooth muscle -- Observations
Rho(D) immune globulin -- Research
Environmental issues
Science and technology
Zoology and wildlife conservation

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