Prediction of the rotational tumbling time for proteins with disordered segments

An ensemble approach to the boundary element method that accurately predicts rotational tumbling time ([tau]c) for well-structured and rigid proteins by introducing two layers of molecular surfaces whose correlated velocities decay exponentially with distance is presented. The reliable prediction obtained by ([tau]c would help to detect intra- and intermolecular interactions and conformational switches between more ordered and less ordered states of the disordered segments.