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Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity

Authors :
Rathinakumar, Ramesh
Walkenhorst, William F.
Wimley, William C.
Source :
Journal of the American Chemical Society. June 10, 2009, Vol. 131 Issue 22, 7609-7617
Publication Year :
2009

Abstract

The biological activity of the selected peptides from the combinatorial library in bacteria, fungi and mammalian cells is studied to characterize the selected peptides and to compare the activity of antimicrobial peptides (AMPs) in vitro and in vivo. The analysis has shown that the methods focusing on screening peptide libraries in vitro for membranes with the appropriate interfacial activity has enabled the design, selection and discovery of novel, potent and broad-spectrum membrane-active antibiotics.

Details

Language :
English
ISSN :
00027863
Volume :
131
Issue :
22
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.202983656