Von Willebrand disease and other bleeding disorders in women: consensus on diagnosis and management from an international expert panel

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2009.04.024 Byline: Andra H. James (a), Peter A. Kouides (b), Rezan Abdul-Kadir (c), Mans Edlund (d), Augusto B. Federici (e), Susan Halimeh (f), Pieter W. Kamphuisen (g), Barbara A. Konkle (h), Oscar Martinez-Perez (i), Claire McLintock (j), Flora Peyvandi (k), Rochelle Winikoff (l) Keywords: coagulation factor; menorrhagia; postpartum hemorrhage; von Willebrand disease; von Willebrand factor Abstract: Reproductive tract bleeding in women is a naturally occurring event during menstruation and childbirth. In women with menorrhagia, however, congenital bleeding disorders historically have been underdiagnosed. This consensus is intended to allow physicians to better recognize bleeding disorders as a cause of menorrhagia and consequently offer effective disease-specific therapies. Author Affiliation: (a) Women's Hemostasis and Thrombosis Clinic, Duke University Medical Center, Durham, NC (b) University of Rochester General Hospital, Rochester, NY (c) Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK (d) Department of Obstetrics and Gynecology, Danderyds Sjukhus AB, Stockholm, Sweden (e) Angelo Bianchi Bonomi Haemophilia Thrombosis Centre, IRCCS Maggiore Policlinico Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy (f) MVZ Labor Duisburg GmbH, Clinical Consultations for Coagulation and Haemophilia Disease, Duisburg, Germany (g) Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands (h) Penn Comprehensive Hemophilia and Thrombosis Program, University of Pennsylvania School of Medicine, Philadelphia, PA (i) Gineguirurgica S.L., Las Rozas, Madrid, Spain (j) University of Auckland, Auckland, New Zealand (k) Angelo Bianchi Bonomi Haemophilia Thrombosis Centre, IRCCS Maggiore Policlinico Hospital, Mangiagalli and Regina Elena Foundation & University of Milan, Milan, Italy (l) CHU Ste-Justine, Montreal, University of Montreal, QC, Canada Article History: Received 14 September 2008; Revised 5 March 2009; Accepted 9 April 2009 Article Note: (footnote) Financial support for this meeting was provided by CSL Behring, Marburg, Germany., Cite this article as: James AH, Kouides PA, Abdul-Kadir R, et al. Von Willebrand disease and other bleeding disorders in women: consensus on diagnosis and management from an international expert panel. Am J Obstet Gynecol 2009;201:12.e1-8.