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Asymmetric synthesis of anti-aldol segments via a nonaldol route: synthetic to statines and (-)-tetrahydrolipstatin
- Source :
- Journal of Organic Chemistry. June 19, 2009, Vol. 74 Issue 12, 4508-4518
- Publication Year :
- 2009
-
Abstract
- An asymmetric synthesis of anti-aldol segments via a nonaldol route is described, where the strategy has involved a highly diastereoselective synthesis of functionalized tetrahydrofuran derivatives from optically active 4-phenylbutyrolactone. The utility of the method is shown by preparing statine derivatives and pancreatic lipase inhibitor, (-)-tetrahydrolipstatin.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 74
- Issue :
- 12
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.206097812