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Inner membrane efflux components are responsible for beta-lactam specificity of multidrug efflux pumps in Pseudomonas aeruginosa
- Source :
- Journal of Bacteriology. Dec, 1997, Vol. 179 Issue 23-24, p7875, 7 p.
- Publication Year :
- 1997
-
Abstract
- Research was conducted to test whether the outer membrane OprM protein influences beta-lactam recognition and efflux in Pseudomonas aeruginosa. The oprM gene was cloned on a SphI fragment into a derivative called pXZL01 while the MexCD-OprM efflux system was constructed and analyzed for reconstitution of efflux activity. Results showed that the efflux components are highly homologous and are characterized by an integral cytoplasmic membrane component, a linker protein and an outer membrane protein.
Details
- ISSN :
- 00219193
- Volume :
- 179
- Issue :
- 23-24
- Database :
- Gale General OneFile
- Journal :
- Journal of Bacteriology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.20775358