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Interaction of human DNA polymerase [alpha] and DNA polymerase I from Bacillus stearothermophilus with hypoxanthine and 8-oxoguanine nucleotides

Authors :
Patro, Jennifer N.
Urban, Milan
Kuchta, Robert D.
Source :
Biochemistry. Sept 1, 2009, Vol. 48 Issue 34, 8271-8278
Publication Year :
2009

Abstract

A study was conducted to analyze human DNA polymerase [alpha], a B family enzyme, and DNA polymerase from Bacillus stearothermophilus (BF). Results indicate that different polymerases interact very differently with base lesions.

Details

Language :
English
ISSN :
00062960
Volume :
48
Issue :
34
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.207814776