Cross coupling of alkyl cobaloximes with maleic anhydrides. Basic studies and applications to the synthesis of chaetomellic acid A anhydride and C-glycosyl maleic anhydrides

Experimental studies involving the techniques developed in cross coupling maleic anhydrides with alkyl cobaloximes are presented. The methods are used in the preparation of C-glycosyl maleic anhydrides and the synthesis of the anhydride of the Ras farnesyl protein transferase inhibitor chaetomellic acid A. This results to the development of a new cross coupling approach for alkyl cobaloximes.